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Physiology and Pharmacology، جلد ۶، شماره ۱، صفحات ۶۷-۷۸
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عنوان انگلیسی Effect of D-glucose injection into ventromedial and lateral nuclei of hypothalamus on pentagastrin-induced gastric secretion in rat
چکیده انگلیسی مقاله It has been shown that those factors which affect gastric acid secretion through the ventromedial and lateral nuclei of hypothalamus, can significantly alter centrally-mediated secretion. There is much evidence that glucose is among these factors that through a central mechanism can decrease induced acid secretion. It appears that this effect is mediated through glucose-sensitive neurons within lateral (LH) and ventromedial (VMH) nuclei of hypothalamus. Therefore, this study was carried out to evaluate the effect of D-glucose injection into LH and VMH on pentagastrin-induced hyperacidity in anesthetized rats. After induction of anesthesia, guide cannula was stereotaxically inserted 1 mm above VMH and/or LH of both sides. Then, after 3-7 days the stomach was washed out, and from 15 min on, sampling (every 5 min) from gastric secretion was done until the end of experiment. Venous infusion of pentagastrin (2 µg/100 g/h) increased acid secretion and it reached to its maximum level after 30 min. The results showed that D-glucose injection (10, 20, 30, and 90 mM) at a rate of 1 µl/rat significantly and in a dose-dependent manner reduce acid secretion, while L-glucose injection (30 mM) or saline solution (154, 169, and 200 mM) did not significantly affect acid secretion. It can be concluded that the VMH and LH contain glucose-sensitive neurons that can influence gastric acid secretion, and D-glucose can be effective on these neurons, which through this way can reduce peripherally-induced hyperacidity. In addition, this effect is stronger at LH than VMH, and the other analogue of glucose (L-glucose) can not affect this phenomenon.
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نویسندگان مقاله افسانه الیاسی | afsaneh elyasi
department of physiology and neuroscience research center, school of medicine, shaheed beheshti university of medical sciences, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مهدی نورالدینی | mahdi noureddini


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-123-16&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research
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