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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۳، صفحات ۲۵۰-۲۶۱
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عنوان انگلیسی Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil
چکیده انگلیسی مقاله Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a promising approach to deal with these obstacles. Niosomal formulations of myrtle essential oil (nMEO) were provided using non-ionic surfactants and cholesterol (Chol). In the next steps, vesicle size, zeta potential, percentage of entrapment efficiency (EE%) and physical stability of nMEO were investigated. Finally, the effect of myrtle essential oil (MEO) and nMEO on microbial growth inhibition were assessed. Values for nMEO size and zeta potential ranged from 6.17 ± 0.32 to 7.24 ± 0.61 (µm) and -20.41 ± 0.17 to -31.75 ± 0.45 (mV), respectively. Higher degrees of EE% were obtained by F6 formulation (Span/Tween 60:Chol (50:50 molar ratio)). Moreover, niosomes have been reported to be stable at 4 °C during a three-month time period. It was revealed that nMEO F6 formulation inhibited growth of Staphylococcus aureus , Staphylococcus epidermidis, Serratia marcescens , and Bacillus subtilis at concentrations lower than that of MEO. Overall, it was found that stable multilamellar vesicles were formed in the presence of 0.5% MEO and F6 formulation. This formulation also exhibited better antibacterial activity than MEO.
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نویسندگان مقاله | Mahboobeh Raeiszadeh
3Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Abbas Pardakhty
1Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Fariba Sharififar
4Hematology and Laboratory Sciences Department, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Alireza Farsinejad
5Physiology Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Mehrnaz Mehrabani
6Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Hossein Hosseini-nave
1Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Mitra Mehrabani


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1829
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-628431.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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