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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۲، صفحات ۱۱۱-۱۲۰
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چکیده فارسی مقاله
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عنوان انگلیسی Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands
چکیده انگلیسی مقاله A novel series of antimony (V) complexes with the hydroxypyranone and hydroxypyridinone ligands were synthesized and characterized by 1 HNMR, FT-IR and electron spin ionization mass spectroscopic (ESI-MS) techniques. The synthesis process involved protection of hydroxyl group followed by the reaction of the intermediate with primary amines and finally deprotection. All compounds were evaluated for in vitro activities against the amastigote and promastigote forms of Leishmania major . Most of the synthesized compounds exhibited good antileishmanial activity against both forms of L. major . IC 50 values of the most active compounds; 9d , 9d and 9e , after 24, 48 and 72 h against amastigote model were 15, 12.5 and 5.5 µg/mL, respectively. 9e , 11 and 9e inhibited the promastigote form of parasite after 24, 48 and 72 h with IC 50 values of 10, 2 and 1 µg/mL, respectively.
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نویسندگان مقاله | Vafa Sheikhmoradi
2Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Sedigheh Saberi
1Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Lotfollah Saghaei
2Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Nader Pestehchian
1Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Afshin Fassihi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1815
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-628504.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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