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Physiology and Pharmacology، جلد ۵، شماره ۲، صفحات ۱۵۳-۱۶۰
عنوان فارسی بررسی و مقایسه درد پس از جراحی در موش های صحرایی معتاد به مرفین و موش های غیر معتاد
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of post-operative pain in morphine-addicted and non-addicted rats
چکیده انگلیسی مقاله Post-operative pain and its management remains one of the most important issues in the field of surgery and health care system. On the other hand, opioid drug abuse has a large prevalence in Iran. Formalin test has been used as a method for assessing pain and analgesia in rats. In the present study, the post-operative pain in morphine addicted rats was compared with that of non-addicted ones using formalin test. For this purpose, 26 rats were chosen and randomly divided into two groups. First group received morphine sulphate in their drinking water for 21 days. The other group received only tap water. On the day of their assessment, a longitudinal incision (1-cm) was made through skin fascia of their plantar aspect of one foot under ether anesthesia. One hour later, their pain was assessed with formalin test through intra-plantar subcutaneous injection of 0.05 ml of 2.5% formalin solution. Our results showed that acute pain (the first 5 minutes after injection) in both groups was not different significantly, but chronic pain (the next 15-45 minutes) was much intense in morphine-addicted rats.
کلیدواژه‌های انگلیسی مقاله Morphine, Post-opeartive Pain, Opioid-related Disorders, Rat
نویسندگان مقاله
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-105-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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