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Physiology and Pharmacology، جلد ۳، شماره ۲، صفحات ۱۳۱-۱۳۹
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عنوان انگلیسی The effect of intracerebroventricular administration of CCK receptor agonist and antagonist in nerve-Iigated mice
چکیده انگلیسی مقاله In the present study the effect of intracerebroventricular (ICV) injection of cerulein, an agonist of CCK receptor and proglumide, a receptor antagonist for hyperalgesia induced by sciatic nerve ligation were investigated in mice. Subcutaneous administration of morphine caused anti-nociception in both intact and nerve-ligated mice. However, the response to opioids was lower in ligated mice as compared to the intact animals. Cerulein induced antinociception only in the nerve-Iigated animals. Combination of cerulein with morphine elicited higher response in both intact and ligated animals. However, the induced response was much prominent in ligated animals. Proglumide alone did not elicit any response in both groups. The antagonist decreased the response of cerulein in the non-ligated mice. In addition a low dose of proglumide in combination with cerulein induced antinociception in the ligated mice. It can be concluded that CCK receptor-related
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نویسندگان مقاله محمدرضا zarrindas | mohammad reza zarrindas
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرزانه samiie | farzaneh samiie


علی اکبر حایری روحانی | ali akbar haeri roohani


سید مهدی رضایت | seyed mahdi rezayat


نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-73-4&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research
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