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Physiology and Pharmacology، جلد ۳، شماره ۱، صفحات ۵۹-۶۵
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عنوان انگلیسی Effects of visual deprivation on epileptic activity in mature rat visual cortex
چکیده انگلیسی مقاله Effects of visual deprivation on the induction of epileptiform activity were studied in layer II/III of mature rat primary visual cortex. Field potentials were evoked by stimulation of layer IV in slices from control and dark-reared (OR) rats. Picrotoxin (PTX)-induced epileptic activity was characterized by spontaneous and evoked epileptic field potentials (EFPs). The results showed that OR slices demonstrate greater susceptibility for induction of spontaneous EFP. PTX-induced changes in the properties of evoked field potentials also showed higher tendency of OR animals to epileptogenesis. In both groups, field potentials are consisted of pEPSP1 (population excitatory post-synaptic potential 1, i.e. first negativity) and pEPSP2 (second negativity). PTX significantly increased the amplitude and duration of pEPSP2, but it had no significant effect on pEPSP1. PTX-induced changes in characteristics of pEPSP2 were significantly higher in OR slices. It is concluded that visual deprivation causes lasting changes in layer II/III of visual cortex that retain in slices and predispose this area for PTX-induced epileptiform activity.
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نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-110-88&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research
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