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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۷، صفحات ۷۳۱-۷۳۷
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عنوان انگلیسی The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart
چکیده انگلیسی مقاله Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-Rb1, adenine 9-β-D-arabinofuranoside (Ara A, specific AMPK inhibitor), and 5'-aminoimidazole-4-carboxamide riboside (Aicar, specific AMPK activator) were administered to rats with HF, singly and/or combinedly. Myocardial high-energy phosphate (such as phosphocreatine, ADP, and ATP), free L-Carnitine, malonyl-CoA, and the activity of FAO-related enzymes in left ventricle from different groups were measured by using the corresponding molecular biological techniques. Results: Gs-Rb1 improved HF significantly, accompanied by a significant increase in phosphocreatine (PCr), ADP, ATP, PCr/ATP ratio, free carnitine, malonyl-CoA, mRNA, activity of carnitine palmitoyltransferase (Cpt), medium-chain Acyl-CoA Dehydrogenase (MCAD) and long-chain acyl-CoA Synthetase (ACSL) and a significant decrease of the ADP/ATP ratio in the left ventricular myocardium. However, all those effects were almost abolished by Ara A and were not further improved by Aicar. Conclusion: Taken together, it suggests that Gs-Rb1 may modulate cardiac metabolic remodeling by improving myocardial fatty acid β-oxidation in failing heart. In addition, the effects of Gs-Rb1 may be mediated via activating AMPK.
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نویسندگان مقاله | Hong-liang Kong
Department of Cardiology, the People’s Hospital of Liaoning Province, i.e. the People’s Hospital of China Medical University, Shenyang, China


| Ai-jie Hou
Department of Cardiology, the People’s Hospital of Liaoning Province, i.e. the People’s Hospital of China Medical University, Shenyang, China


| Ning-ning Liu
Clinical Ophthalmology, the First Affiliated Hospital, China Medical University, Shenyang, China


| Bo-han Chen
Dalian Medical University, Dalian, China


| Hua-ting Huang
Department of Cardiology, the People’s Hospital of Liaoning Province, i.e. the People’s Hospital of China Medical University, Shenyang, China


| Sheng-nan Dai
Department of Cardiology, the People’s Hospital of Liaoning Province, i.e. the People’s Hospital of China Medical University, Shenyang, China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10799.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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