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Iranian Journal of Microbiology، جلد ۱۰، شماره ۲، صفحات ۸۲-۸۹
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عنوان انگلیسی Genetic diversity of Staphylococcus aureus strains from a teaching hospital in Isfahan, Iran: The emergence of MRSA ST639- SCCmec III and ST343- SCCmec III
چکیده انگلیسی مقاله Background and Objectives: Staphylococcus aureus is an important pathogen that can be colonized in the nose and increase the risk of spreading infections in hospitals. The present study aimed at determining the phenotypic and genotypic characterization of S. aureus strains isolated from patients and healthcare workers (HCWs) from a teaching hospital in Isfahan, Iran. Materials and Methods: This cross-sectional study was performed on 262 nasal swabs and 23 clinical isolates that were collected from a teaching hospital during February and April 2016. Staphylococcal cassette chromosome mec (SCC mec ) and multilocus sequence typing (MLST) were performed for selected isolates. Results: Overall, 23% and 18% of healthcare workers and patients were carriers, respectively. Methicillin-resistant S. aureus (MRSA) rate was 13%, 33% and 52% in nasal HCWs, nasal patients, and clinical samples, respectively. The molecular typing of MRSA isolates revealed that the most common SCC mec type is SCC mec type III (88%). The highest rate of resistance was observed against tetracycline and erythromycin, with 48.7%. The most frequently detected toxin genes among S. aureus isolates were hla (99%) and sea (44%), moreover, pvl genes were detected in (40%) of MRSA isolates. The results of MLST showed 7 different sequence types (STs): ST859 (2/9), ST6 (2/9), ST639 (1/9), ST343 (1/9), ST239 (1/9), ST291 (1/9) and ST25 (1/9). Conclusion: Our results revealed that ST clones associated with healthcare-associated MRSA (HA-MRSA) are actively circulating among nasal carriage in our healthcare setting, and thus, effective infection control policies are needed to reduce nasal carriage in healthcare settings.
کلیدواژه‌های انگلیسی مقاله MRSA, MLST, Nasal carrier, SCCmec typing
نویسندگان مقاله | Hossein Sedaghat
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Bahram Nasr Esfahani
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Mehrdad Halaji
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Azhar Sallari Jazi
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Sina Mobasherizadeh
Department of Endodontics, Dental School, Khorasgan University, Isfahan, Iran


| Seyed Rohollah Havaei
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Emaneini
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Seyed Asghar Havaei


نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/1530
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/91/article-91-639379.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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