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Iranian Biomedical Journal، جلد ۲۰، شماره ۴، صفحات ۲۱۷-۲۲۲
عنوان فارسی Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid
چکیده انگلیسی مقاله Background: Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. Methods: Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administered to the rats with APAP-induced liver damage. The isolated liver cells were infused intraperitoneally into rats. Blood samples were obtained to evaluate the changes in the serum liver enzymes, including activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and the level of serum albumin. To assess the engraftment of infused hepatocytes, rats were euthanized, and the liver DNA was used for PCR using sex-determining region Y (SRY) primers. Results: The levels of AST, ALT and ALP in the serum of rats with APAP-induced liver injury were significantly increased and returned to the levels in control group by day six. The APAP-induced decrease in albumin was significantly improved in rats through cell therapy, when compared with that in the APAP-alone treated rats. SRY PCR analysis showed the presence of the transplanted cells in the liver of transplanted rats. Conclusion: Stearic acid-rich diet in combination with cell therapy accelerates the recovering of hepatic dysfunction in a rat model of liver injury.
کلیدواژه‌های انگلیسی مقاله Stearic acid, Liver failure, Transplantation
نویسندگان مقاله ناصر هاشمی گورادل | nasser hashemi goradel


محمد علی اقبال | mohammad ali eghbal


مسعود دارابی | masoud darabi


لیلا روشنگر | leila roshangar


مریم اسدی | maryam asadi


نصرت اله ضرغامی | nosratollah zarghami


محمد نوری | mohammad nouri


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-604&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Medical Biotechnology
نوع مقاله منتشر شده مقاله کامل
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