این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۲۰، شماره ۱، صفحات ۱-۱۱
عنوان فارسی Toxicity of Nanoparticles and an Overview of Current Experimental Models
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Toxicity of Nanoparticles and an Overview of Current Experimental Models
چکیده انگلیسی مقاله Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Cell inflammatory response induced by NPs is checked by measuring inflammatory biomarkers, such as IL-8, IL-6, and tumor necrosis factor, using ELISA. Lactate dehydrogenase (LDH) assay is used for cell membrane integrity. Different types of cell cultures, including cancer cell lines have been employed as in vitro toxicity models. It has been generally agreed that NPs interfere with either assay materials or with detection systems. So far, toxicity data generated by employing such models are conflicting and inconsistent. Therefore, on the basis of available experimental models, it may be difficult to judge and list some of the more valuable NPs as more toxic to biological systems and vice versa. Considering the potential applications of NPs in many fields and the growing apprehensions of FDA about the toxic potential of nanoproducts, it is the need of the hour to look for new internationally agreed free of bias toxicological models by focusing more on in vivo studies.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله حاجی bahadar | haji bahadar


فهیم maqbool | faheem maqbool


کمال نیاز | kamal niaz


محمد عبداللهی | mohammad abdollahi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-573&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله مروری
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات