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Iranian Biomedical Journal، جلد ۱۶، شماره ۲، صفحات ۵۹-۶۷
عنوان فارسی اثرات دوگانه آتورواستاتین بر روی آنژیوژنز؛ پرولیفراسیون سلول های اپیدرمال و تومور زایی در پوست در مدل های حیوانی
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عنوان انگلیسی Ambivalent Effects of Atorvastatin on Angiogenesis, Epidermal Cell Proliferation and Tumorgenesis in Animal Models
چکیده انگلیسی مقاله Background: A growing body of preclinical data indicates that statins may possess antineoplastic properties however, some studies have raised the possibility that statins may also have carcinogenic potential. Methods: An air pouch model was used for angiogenesis. Single or multiple applications of croton oil on the back of Swiss albino mice with or without initiation by dimethylbenz(a)antheracene (DMBA) were used to evaluate the skin tumorgenesis, ultrastructural and histological alterations. Results: Atorvastatin (orally, 10 mg/kg/day) produced a significant (P< 0.05) reduction in angiogenesis. Concurrent administration of mevalonate reversed the anti-angiogenic effect of atorvastatin. However, local injection of atorvastatin (200 µg) into the pouches induced a significant (P< 0.5) increase in angiogenesis that was not reversed by co-administration of mevalonate. The disturbance of cell polarity, inflammatory response, thickness of epidermal layer, and mitotic index induced by croton oil were inhibited markedly and dose-dependently (P< 0.001) by pre-treatment with atorvastatin. In spite of the strong anti-inflammatory and anti-proliferative effects of atorvastatin on epidermal cell proliferation, it was identified that the same doses of atorvastatin in DMBA-initiated and croton oil-promoted skin tumorgenesis in mice increased the incidence of tumors and their conversion into malignant carcinoma. Conclusion: The reasons for these discrepancies remain unclear, and could be related to ambivalent effects of atorvastatin on angiogenesis or to specific differences in the experimental conditions. It is suggested that the pro-angiogenic effect of the drug, which could be responsible for promotion of skin tumors, is independent of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition that can be mediated directly by atorvastatin.
کلیدواژه‌های انگلیسی مقاله Atorvastatin, Angiogenesis, Cell Proliferation, Cancer
نویسندگان مقاله علیرضا گرجانی | alireza garjani


حسن رضازاده | hassan rezazadeh


سینا عندلیب | sina andalib


مجتبی ضیایی | mojtaba ziaee


یوسف دوستار | yousef doustar


حمید ثریا | hamid soraya


مهراوه گرجانی | mehraveh garjani


آرش خرمی | arash khorrami


مصطفی اسدپور | mostafa asadpoor


نسرین مالکی دیزجی | nasrin maleki dizaji


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-357&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
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