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Iranian Biomedical Journal، جلد ۱۵، شماره ۱، صفحات ۵۱-۵۸
عنوان فارسی تغییرات نوروپاتولوژیک در کورتکس مغز و هیپوکامپ مدل آلزایمر موش صحرایی
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عنوان انگلیسی Neuropathological Changes in Brain Cortex and Hippocampus in a Rat Model of Alzheimer’s Disease
چکیده انگلیسی مقاله Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned to three groups: control, sham and β-amyloid (Aβ) injection. For behavioral analysis, Y-maze and shuttle box were used, respectively at 14 and 16 days post-lesion. For histological studies, Nissl, modified Bielschowsky and modified Congo red staining were performed. The lesion was induced by injection of 4 µL of Aβ (1-40) into the hippocampal fissure. Results: In the present study, Aβ (1-40) injection into hippocampus could decrease the behavioral indexes and the number of CA1 neurons in hippocampus. Aβ injection CA1 caused Aβ deposition in the hippocampus and less than in cortex. We observed the loss of neurons in the hippocampus and cerebral cortex and certain subcortical regions. Y-maze test and single-trial passive avoidance test showed reduced memory retention in AD group. Conclusion: We found a significant decreased acquisition of passive avoidance and alternation behavior responses in AD group compared to control and sham group (P< 0.0001). Compacted amyloid cores were present in the cerebral cortex, hippocampus and white matter, whereas, scattered amyloid cores were seen in cortex and hippocampus of AD group. Also, reduced neuronal density was indicated in AD group.
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نویسندگان مقاله ملیحه نوبخت | maliheh nobakht


سیدمحمد حسینی | seyed mohammad hoseini


پژمان مرتضوی | pejman mortazavi


ایرج سهرابی | iraj sohrabi


بنفشه اسماعیل زاده | banafshe esmailzade


ناهید رهبر روشندل | nahid rahbar rooshandel


شیلا امید ظهیر | shila omidzahir


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-160&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
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