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Iranian Biomedical Journal، جلد ۱۲، شماره ۳، صفحات ۱۴۳-۱۵۲
عنوان فارسی Beta Cell Protective Effects of Sodium Tungstate in Streptozotocin-Induced Diabetic Rats: Glycemic Control, Blockage of Oxidative Stress and Beta Cell Histochemistry
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عنوان انگلیسی Beta Cell Protective Effects of Sodium Tungstate in Streptozotocin-Induced Diabetic Rats: Glycemic Control, Blockage of Oxidative Stress and Beta Cell Histochemistry
چکیده انگلیسی مقاله Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic rats from one week before STZ injection (TDB), food-restricted diabetic (FRD), tungstate treated control, sodium tungstate treated diabetic rats from one week after STZ administration (TDA). We evaluated serum insulin, glucose and glucose tolerance liver glycogen content, glucokinase (GK) activity blood and pancreas antioxidant power, lipid peroxidation and fuchsin-aldehyde histochemical staining of beta-cells. Results: Blood glucose levels of TDB group were lower than other diabetic groups (P< 0.01). Blood insulin levels of all diabetic groups were lower than controls (P< 0.01). Glucose intolerance improved in TDB animals. Blood and pancreas antioxidant power, liver glycogen contents and GK activities and granulated beta cells increased in TDB rats in comparison with other diabetic groups (P< 0.01). Likewise, lipid peroxidation decreased significantly in TDB rats (P< 0.01). Conclusions: Results suggested that sodium tungstate if administrated before STZ injection improves glycemic state by a direct effect on pancreatic beta-cells and preserves them by reducing the activity of these cells at the time of STZ injection, reducing STZ-induced oxidative stress, reducing insulin secretion, or all of the above mentioned.
کلیدواژه‌های انگلیسی مقاله Diabetes mellitus, Sodium tungstate, Beta cells
نویسندگان مقاله زهرا حیدری | zahra heidari


مهدی هراتی | mehdi harati


حمیدرضا محمودزاده ثاقب | hamid reza mahmoudzadeh sagheb


بیتا مودی | bita moudi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-48&slc_lang=en&sid=en
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