این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۱۲، شماره ۳، صفحات ۱۷۹-۱۸۴
عنوان فارسی L-Arginine Supplementation Influenced Nitrite but Not Nitrate and Total Nitrite in Rabbit Model of Hypercholesterolemia
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی L-Arginine Supplementation Influenced Nitrite but Not Nitrate and Total Nitrite in Rabbit Model of Hypercholesterolemia
چکیده انگلیسی مقاله Background: The assessment of altered nitric oxide (NO) availability is of potentially important diagnostic and prognostic significance. The present study is aimed to investigate the effect of L-arginine (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production. Methods: White male rabbits (n = 30) randomly assigned to 2 groups. Rabbits were fed 1% high-cholesterol diet (HC group, n = 15), or HC diet with oral L-arginine (3% in drinking water) (HC + L-arginine group, n = 15) for 4 weeks. The serum levels of lipids, L-arginine, total NO metabolites (NOx), nitrite and nitrate were measured before and after the study. Results: In this study, L-arginine supplementation led to a significant increased plasma level of L-arginine. The serum level of nitrite was significantly higher in L-arginine treated group while serum level of nitrate and NOx was significantly lower than HC group. Conclusion: As the result of our study showed, nitrite is a useful marker of endogenous endothelial NO production and although frequently used, neither nitrate nor NOx are reliable markers of acute changes in endothelial NO synthase activity.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شقایق حق جوی جوانمرد | shaghayegh haghjooy javanmard


مهدی نعمت بخش | mehdi nematbakhsh


علیرضا منجمی | alireza monajemi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-47&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله کامل
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات