این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۱۱، شماره ۲، صفحات ۱۰۱-۱۱۱
عنوان فارسی مطالعه تغییرات مارکرهای پاتوفیزیولوژی استرس در سنین مختلف مدل حیوانی در استرس حرارتی مزمن و حاد
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Study of Changes in Some Pathophysiological Stress Markers in Different Age Groups of an Animal Model of Acute and Chronic Heat Stress
چکیده انگلیسی مقاله This study demonstrates the changes in six different pathophysiological parameters such as body weight, body temperature, fecal pellet count, blood-brain barrier (BBB) permeability, plasma corticosterone level and emergence of hemorrhagic peptic ulcer spots due to exposure to high environmental heat in three different age groups of freely moving rats. Methods: Each age group of rats was sub divided into three groups: (i) acute heat stress-subjected to a single exposure for four hours in the Biological Oxygen Demand incubator at 38°C (ii) chronic heat stress-exposed for 21 days daily for one hour in the incubator at 38°C, and (iii) handling control groups. The data were recorded for the analyses of the changes in different parameters just after the heat exposure from acute stressed rats and on 1st, 3rd, 6th, 9th, 12th, 15th, 18th and 21st day on chronic stressed rats for body temperature, body weight, fecal pellets count. For the analysis of changes in three other parameters, BBB permeability, plasma corticosterone level and peptic ulcer spots following chronic exposure to high environmental heat, data were recorded on 22nd day for the analysis. Results: Analysis of variance (ANOVA-1) of the observations demonstrates a significant increase in body temperature, fecal pellet count, BBB permeability (except in adult group), plasma corticosterone level and emergence of hemorrhagic peptic ulcer spots in all three different age group of rats due to exposure to acute heat stress. However, chronic heat was found responsible for the significant reduction in body weight in weaning and young rats, increase in body temperature, number of fecal pellets excreted (in early days of chronic stress) and number of peptic ulcer spots in all three age groups of rats. At the same time, BBB extravasations were not observed in rats except very mild in weaning group. Conclusion: The results of the present study indicate that the acute as well as chronic exposure to hot environment significantly alters the physiology of different organs of the body.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله راکش کومار sinha | rakesh kumar sinha


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-92&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله کامل
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات