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Iranian Biomedical Journal، جلد ۱، شماره ۴، صفحات ۱-۹
عنوان فارسی Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p۵۳
چکیده فارسی مقاله Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin in‌hibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies.
کلیدواژه‌های فارسی مقاله HIV، TAT، Transcription، Cell cycle، p53
عنوان انگلیسی Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53
چکیده انگلیسی مقاله Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin in‌hibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies.
کلیدواژه‌های انگلیسی مقاله HIV, TAT, Transcription, Cell cycle, p53
نویسندگان مقاله ژانت duvall | janet duvall


فتاح کاشانچی | fatah kashanchi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-441&slc_lang=en&sid=en
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