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Research Journal of Pharmacognosy، جلد ۵، شماره ۳، صفحات ۳۱-۳۹
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عنوان انگلیسی Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil
چکیده انگلیسی مقاله Background and objectives: Although weed plants are considered undesirable in a particular situation, some weed seeds can be a valuable and cheap source of therapeutic natural compounds. Securigera securidaca (L.) Degen & Dorfl (Fabaceae) is widely distributed in Europe, Australia and Asia as a weed plant. This study investigated the bioactive compounds of S. securidaca seeds as well as its potential anti-inflammatory properties. Methods:  The fatty acid and sterol content were investigated with gas chromatography–mass spectrometry (GC-MS) and phenolic compounds were detected using high performance thin layer chromatography (HPTLC). The thermostability of the oil was studied using differential scanning calorimetry (DSC). Formalin-induced paw licking test and myeloperoxidase activity were investigated. The study was conducted by creating six groups of rats including a control group (vehicle-treated rats, 250 µL/kg, i.p.), formalin group (50 µL of 2.5% formalin), positive control (paracetamol, 100 mg/kg, i.p), and groups of S. securidaca seed oil (250, 500, 1000, 2000, and 4000 μl/kg, i.p). Results: S. securidaca seeds contained a high level of polyunsaturated fatty acid content including linoleic acid (64.602 ± 0.793%) and oleic acid (15.353 ± 0.461%). Stigmasterol and campesterol were not detected in the oil but it contained esterified β-sitosterol (6.621 ± 0.08 mg/g). The seed oil couldn't create a significant reduction in the MPO activity. It showed a slight but not significant effect on formalin-induced pain reduction. Conclusion: The seed is a rich source of linoleic acid which makes it a good candidate to be used in the pharmaceutical industry. 
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نویسندگان مقاله Akram Jamshidzadeh |
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Ardalan Pasdaran |
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Reza Heidari |
Department of Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Azadeh Hamedi |
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_64870_4cf277a4b497cd8cc247d947c1bd41a2.pdf
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