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Archives of Anesthesiology and Critical Care، جلد ۴، شماره ۳، صفحات ۴۹۷-۵۰۰
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عنوان انگلیسی Effect of Ketamine-Sufentanil and Ketamine-Midazolam to induce sedation and analgesia in Pediatric with Lumbar Puncture or Bone Marrow Aspiration
چکیده انگلیسی مقاله Background: The combination of sedative and analgesic drugs has a favorable effect on pain management and sedation during painful procedures in pediatrics. Therefore, our aim was to compare the effect of sedation and analgesia of ketamine-sufentanil and ketamine-midazolam in painful procedures in children with blood malignancies. Methods: This double-blind, clinical trial was performed on 82 children with malignancy who had indication of painful diagnostic intervention; patients were randomly divided into two groups of ketamine-sufentanil (KS) and ketamine -midazolam (KM). In KS group, sufentanil 0.5mcg/ kg and ketamine 1mg/ kg and in the KM group, ketamine 1mg/ kg, and midazolam 0.1mg/ kg bolus were prescribed. In either group, hemodynamic indicators of sedation, side effects, duration of effectiveness were recorded. Data were analyzed using SPSS 20. Results: Sedation based on Ramsay sedation score was not significantly different between the two groups (p= 0.39). The average recovery time in the midazolam-ketamine group was higher (p-value= 0.076). Conclusion: The combination of ketamine-sufentanil and ketamine-midazolam was effective in sedation and analgesia in bone marrow aspiration and lumber puncture; side effects were however, lower in ketamine-midazolam group.
کلیدواژه‌های انگلیسی مقاله ketamine,sufentanil,midazolam,pediatric
نویسندگان مقاله | Hamidreza Shetabi
Isfahan University of Medical Sciences


| Amir Shafa
Department of Anesthesia, Al-Zahra Medical Center, Isfahan, Iran.


| Mohamadmehdi Zare


نشانی اینترنتی http://aacc.tums.ac.ir/index.php/aacc/article/view/179
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/371/article-371-684514.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research Article(s)
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