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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۸، صفحات ۸۴۸-۸۵۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats
چکیده انگلیسی مقاله Objective(s): Nowadays, Di-(2-ethylhexyl) phthalate (DEHP) is widely used in different kinds of commercial products as a plasticizer. Previous studies have revealed that exposures to DEHP could be associated with precocious puberty in teenagers, but the exact mechanism is yet to be known. Materials and Methods: In this study, 48 prepubertal Wistar female rats were randomly apportioned into 4 groups and orally treated with 0, 250, 500, and 1000 mg/kg/d DEHP from postnatal day 21 up to 4 weeks. Subsequently, we examined the indicators related to the initiation of sexual development. Results: DEHP was able to shorten the vaginal opening time and prolong the estrous cycles of female rats. IGF-1 expression was significantly upregulated by 1000 mg/kg/d DEHP in the hypothalamus, and the hypothalamic, as well as serum levels of GH, were also upregulated by DEHP. It also caused decrements in serum levels of FSH, LH, and T and the increment in level of progesterone. Meanwhile, DEHP was able to exert its effect on the mRNA and protein expression levels of Kiss-1, GPR54, and GnRH in the hypothalamus in pubertal female rats. Conclusion: These findings are revealing that DEHP exposure more likely causes imbalances of hypothalamus functioning in pubertal female rats and thus induces precautious puberty in these animals.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Te Liu
Scientific Research Center, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China


| Yuzhuo Wang
Department of Orthodontics, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China


| Modi Yang
Department of Orthopedics, China-Japan :union: Hospital of Jilin University, Changchun 130033, China


| Pu Shao
Scientific Research Center, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China


| Lian Duan
Scientific Research Center, China-Japan :union: Hospital of Jilin University, Changchun, China.


| Meng Li
Scientific Research Center, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China


| Mingji Zhu
Department of Dermatological, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China


| Jie Yang
Department of Endocrinology, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China


| Jinlan Jiang
Scientific Research Center, China-Japan :union: Hospital of Jilin University, Changchun, 130033, China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11026.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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