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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۴، صفحات ۳۱۶-۳۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of metformin on morphine analgesic tolerance and dependence in rats
چکیده انگلیسی مقاله Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in rats. For induction of tolerance, morphine sulfate was injected (10 mg/kg, twice a day, s.c.) for 7 days. Animals received metformin (5 and 50 mg/kg, orally, daily) during the examination period for assessing the development of morphine tolerance and dependence. In order to evaluate the expression of morphine tolerance and dependence, single doses of MET (5 and 50 mg/kg, orally) were administered on day 7. Tail flick test was performed to assess the induction of morphine tolerance. For evaluation of morphine dependence, naloxone-induced jumping (5 mg/kg, s.c.) was monitored. Our results showed that 7 days coadministration of 50 mg/kg of MET significantly reduced the development of morphine analgesic tolerance versus morphine + saline treated rats ( P < 0.001). Treatment with 50 mg/kg MET reduced the incidence and frequency of jumping in naloxone injected animals ( P < 0.01). It is notable that single dose administration of MET, did not prevent the expression of analgesic tolerance and physical dependence to morphine. Based on these results, it can be concluded that MET attenuates the development of morphine analgesic tolerance and dependence in rats.
کلیدواژه‌های انگلیسی مقاله Metformin,Morphine,Physical dependence,Tolerance
نویسندگان مقاله | Iman Fatemi
1Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Morteza Amirteimoury
1Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran. 2Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Ali Shamsizadeh
1Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran. 2Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Ayat Kaeidi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1835
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-689401.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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