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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۴، صفحات ۳۶۸-۳۷۶
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عنوان انگلیسی Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus
چکیده انگلیسی مقاله Oxidative stress (OS) is a main mechanism in organophosphorus poisoning. The effects of calcium channel blockers have been confirmed in decreasing of oxidative stress. In the current study, the effects of amlodipine (AM), as a calcium channel blocker, were evaluated on oxidative damages induced by diazinon (DZN) in hippocampus tissue of Wistar rats. Forty-two rats were divided into six groups and treated intraperitoneally for two weeks. Group 1 served as control received vehicle, group 2 was treated with 9 mg/kg of AM, group 3 (positive control) received DZN (32 mg/kg), Groups 4, 5, and 6 were treated with 3, 6, and 9 mg/kg of AM adjunct with DZN (32 mg/kg), respectively. After 14 days, all the animals were sacrificed under anesthesia and hippocampus tissue and blood samples were collected for biochemical analysis and histopathology experiments. The results showed that DZN caused significant increase in lipid peroxidation ( P < 0.001), nitric oxide ( P < 0.001) and lactate dehydrogenase ( P < 0.001) levels, depletion of total antioxidant capacity ( P < 0.01), and structural changes in hippocampus tissues. Following AM administration, a significant improvement was observed in oxidative biomarkers in hippocampus tissues. Additionally, our biochemical findings were related well with histopathological examinations. In conclusion, the data of this study indicated that AM administration may prevent oxidative damages via improving of energy production and preventing of free radical formation in DZN-exposed animals.
کلیدواژه‌های انگلیسی مقاله Amlodipine,Calcium channel blocker,Diazinon,Hippocampus.
نویسندگان مقاله | Amir Nili-Ahmadabadi
1Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, I.R. Iran. 2Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Fahimeh Ali-Heidar
1Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, I.R. Iran. 2Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Akram Ranjbar
3Department of Clinical Sciences, School of Medical Sciences, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Leila Mousavi
1Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, I.R. Iran. 2Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Davoud Ahmadimoghaddam
1Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, I.R. Iran. 2Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Amir Larki-Harchegani
4Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, I.R. Iran.


| Abolfazl Ghafouri-Khosrowshahi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1845
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-689407.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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