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Iranian Journal of Toxicology، جلد ۱۰، شماره ۲، صفحات ۲۳-۲۸
عنوان فارسی Effect of Sodium Metabisulfite on Rat Ovary and Lipid Peroxidation
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله Lipid Peroxidation، Ovary، Sodium Metabisulfite
عنوان انگلیسی Effect of Sodium Metabisulfite on Rat Ovary and Lipid Peroxidation
چکیده انگلیسی مقاله Background: Many health problems are related to lifestyle and dietary factors. Since ancient times, food additives such as sulfites have been used to preserve foods. Diverse effects of sulfites on multiple organs have been reported but its effect on female reproductive organ has not been fully elucidated. The aim of this study was to investigate the effects of sodium metabisulfite (SMB) on ovarian tissue in adult rats. Methods: Four groups of female rats (n=32) were used. The experimental rats received 10, 100 and 260 mg/kg SMB for 28 days (S10, S100 and S260 groups, respectively). The control rats received distilled water for the same period. The ovarian volume, weight and the number of different types of follicles were estimated by stereological methods. Lipid peroxidation is assessed indirectly by the measurement of malondialdehyde (MDA), using the thiobarbituric acid (TBA) method. Results: The results showed a significant decrease in the ovarian volume, the number of primordial, primary, secondary, grafian follicles and corpus luteum in the SMB-treated animals compared with the control group (P < 0.05). In comparison to the control group, the number of atretic follicles increased in the SMB-treated rats. MDA was significantly increased in S260 group compared to the control group. Conclusion: The present data confirm sulfite-induced structural changes in the ovary. Increased level of MDA because of SMB ingestion suggests that free radicals may have a critical role in these changes.
کلیدواژه‌های انگلیسی مقاله Lipid Peroxidation, Ovary, Sodium Metabisulfite
نویسندگان مقاله ناهید رضایی | nahid rezaee
department of physiology, arsanjan branch, islamic azad university, arsanjan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

زهرا نعمت اللهی | zahra nematollahi
department of physiology, arsanjan branch, islamic azad university, arsanjan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شهناز شکرفروش | shahnaz shekarforous
department of physiology, arsanjan branch, islamic azad university, arsanjan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ابراهیم حسینی | ebrahim hoseini
department of biology, marvdasht branch, islamic azad university, marvdasht, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-316-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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