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Iranian Journal of Toxicology، جلد ۱۰، شماره ۱، صفحات ۴۹-۵۲
عنوان فارسی Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose
چکیده فارسی مقاله
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عنوان انگلیسی Comparison of Effects and Side Effects of Two Naloxone-Based Regimens in Treatment of Methadone Overdose
چکیده انگلیسی مقاله Background: Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone. Methods: In this single-blind clinical trial, 80 patients with methadone overdose syndrome were randomly divided into two equal groups. The patients in infusion group received a constant infusion of naloxone preparation while in the patients in PRN group, naloxone was administered only if needed clinically. Severity of withdrawal syndrome was evaluated after 30 min, 3 h, and 12 h of the treatments in both groups. Results: Eighty patients completed the study (10 women and 70 men). Both groups were similar in terms of mean age, sex ratio, and the severity of intoxication. The severity of withdrawal symptom was significantly lower in the PRN group (P< 0.001). Conclusion: Naloxone administration as PRN mode lowers the rate and severity of withdrawal syndrome. It is recommended as the preferred mode of naloxone administration.
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نویسندگان مقاله آرش یزدان بخش | arash yazdanbakhsh
department of emergency medicine, arak university of medical science, arak, iran.

سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

محمد کاظمی فر | mohammad kazemifar
department of toxicology, qazvin university of medical science, qazvin, iran.


کامیار نظری | kamyar nazari
md, arak university of medical science, arak, iran.

سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

بهمن صادقی | bahman sadeghi
department of social medicine, arak university of medical science, arak, iran.

سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

حسن صلحی | hassan solhi
department of toxicology, arak university of medical science, arak, iran.

سازمان اصلی تایید شده: دانشگاه اراک (Arak university)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-330-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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