این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۹، شماره ۳۰، صفحات ۱۴۰۲-۱۴۰۶
عنوان فارسی Effects of Chronic Exposure to Sodium Arsenate on Kidney of Rats
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله Histo-Pathology، Kidney، Rat، Sodium Arsenate.
عنوان انگلیسی Effects of Chronic Exposure to Sodium Arsenate on Kidney of Rats
چکیده انگلیسی مقاله Background: In the present study, histopathological effects of chronic exposure to sodium arsenate in drinkable water were studied on a quantity of organs of rat. Methods: Rats were divided into two groups, group I served as control group, were main-tained on deionized drinkable water for 2 months, and group II the study group were given 60 g/ml of sodium arsenate in deionized drinkable water for 2 months. Blood and urine samples from two groups of animals were collected under anesthesia and the animals were sacrificed under deep anesthesia (a-chloralose, 100 mg/kg, I.P). Their kidney, liver, aorta, and heart were dissected out and cleaned of surrounding connective tissue. The organs were kept in formaldehyde (10%) for histopathologic examination. Serum and urine samples from two groups were collected and analyzed for arsenic level. Total quantity of arsenic in serum and urine of animal was measured through graphic furnace atomic absorption spectrometry (GF-AAS). Results: Examination with light microscopy did not show any visible structural changes in the aorta, myocardium, and liver of chronic arsenic treated animals.However, a significant effect was observed in the kidneys of chronic arsenic treated rats showing distinct changes in proxi-mal tubular cells. There was high concentration of arsenic in serum and urine of arsenic ex-posed animals (group II) significantly (P< 0.001). Conclusion: Swollen tubular cells in histopathologic study of kidney may suggest toxic effects of arsenic in the body.
کلیدواژه‌های انگلیسی مقاله Histo-Pathology, Kidney, Rat, Sodium Arsenate.
نویسندگان مقاله نامدار یوسف وند | namdar yousofvand
department of biology, university of razi, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

محمد فهیم | mohammad fahim
department of physiology, vallabhbhai patel chest institute, university of delhi, delhi, india.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-83-4&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات