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Iranian Journal of Toxicology، جلد ۸، شماره ۲۷، صفحات ۱۱۶۰-۱۱۶۷
عنوان فارسی The Protective Roles of Zinc and Magnesium in Cadmium-Induced Renal Toxicity in Male Wistar Rats
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله Cadmium،Magnesium، Renal Function، Zinc.
عنوان انگلیسی The Protective Roles of Zinc and Magnesium in Cadmium-Induced Renal Toxicity in Male Wistar Rats
چکیده انگلیسی مقاله Background: Cadmium (Cd) is a heavy metal that has widespread use. It enters the food chain in different ways, including soil and water. Cadmium can cause dysfunction of different body organs. Zinc (Zn) and magnesium (Mg) supplementation can have protective effects against cadmium toxicity due to their antagonistic and antioxidants properties. This study examines the influence of supplemental Zn and Mg on Cd renal toxicity. Methods: Young male Wistar rats were divided into six groups of five. The Cd group received 1 mg Cd/kg and the control group received 0.5 mg/kg normal saline (i.p.). The other four groups were administered 1 mg/kg Cd+0.5 mg/kg Zn, 1 mg/kg Cd+1.5 mg/kg Zn, 1 mg/kg Cd+ 0.5 mg/kg Mg, and 1 mg/kg Cd+ 1.5 mg/kg Mg (i.p.) for 21 days. Then, serum sodium, potassium, urea, creatinine, and protein levels were measured. Results: The results indicated that creatinine and proteinlevels decreased while urea, sodium, and potassiumlevels increased as a result of Cd exposure. Co-administered Cd and Zn and Mg decreased urea and increased sodium serum level in comparison to the cadmium group. Treatment by Mg, contrary to co-administered Cd and Zn, reduced serum protein level compared to the cadmium group. Compared to the cadmium treated group, Zn and Mg treatment enhanced serum creatinine level and reduced serum potassium level. Conclusion: The findings seem to suggest that zinc and magnesium compounds,due to their antagonistic and antioxidant activities, can protect Cd renal toxic effectsin a dose-dependent manner.
کلیدواژه‌های انگلیسی مقاله Cadmium,Magnesium, Renal Function, Zinc.
نویسندگان مقاله نسیم بابک نژاد | nasim babaknejad
department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

علی اصغر مشتاقی | ali asghar moshtaghie
department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

کهین شاهین پور | kahin shahanipour
department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سمیه بهرامی | somaye bahrami
department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-238-2&slc_lang=en&sid=en
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