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Iranian Journal of Toxicology، جلد ۸، شماره ۲۴، صفحات ۹۹۱-۹۹۷
عنوان فارسی Influence of Aluminium Chloride on Antioxidant System in the Testis and Epididymis of Rats
چکیده فارسی مقاله
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عنوان انگلیسی Influence of Aluminium Chloride on Antioxidant System in the Testis and Epididymis of Rats
چکیده انگلیسی مقاله Background:In recent years, the use of chemicals in agriculture, industry, and public health has become so common that the environment is continuously contaminated by the toxic substance-like metals. Aluminum released due to anthropogenic activities such as mining and industrial uses. Aluminium has several industrial uses. The present study was designed to investigate the effect of aluminium chloride (AlCl3) on enzymatic and non-enzymatic antioxidants in the testis and epididymis of rats. Methods:Adult male rats were administered with aluminium chloride at two different doses, 50 mg and 100 mg/kg body weight, orally, daily for 45 days. At the end of the experimental period, the animals were sacrificed and their testis and the epididymis were removed. Antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-s-transferase (GST) were assayed. Lipid peroxidation (LPO), vitamin C, and vitamin E levels were also determined. Results:Aluminium chloride administration had no effect on the bodyweight of the animals but the weight of the testis and epididymis was decreased. Almost all the antioxidant enzymes studied markedly diminished in the testis and epididymis of aluminium chloride treated animals. The non-enzymatic antioxidants, vitamin C and vitamin E, also declined. Lipid peroxidation, on the other hand, significantly increased. The influence was found to be more in 100 mg treated rats when compared to 50 mg treated rats. Conclusions:The present study suggests the reproductive toxicity of aluminium by inducing the oxidative stress in the testis and epididymis and possible interference in sperm production and further maturational processes
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نویسندگان مقاله arumugam kalaiselvi | arumugam kalaiselvi
department of zoology, k.m.centre for post graduate studies, puducherry, india


onorine marcelline suganthy | onorine marcelline suganthy
research and development centre, bharathiar university, coimbatore, india.


palaniandy govindassamy | palaniandy govindassamy
research and development centre, bharathiar university, coimbatore, india.


dasal vasantharaja | dasal vasantharaja
department of zoology, k.m.centre for post graduate studies, puducherry, india


balaji gowri | balaji gowri
department of zoology, k.m.centre for post graduate studies, puducherry, india


venugopal ramalingam | venugopal ramalingam
department of zoology, k.m.centre for post graduate studies, puducherry, india
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-144&slc_lang=en&sid=en
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