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Iranian Journal of Toxicology، جلد ۷، شماره ۲۳، صفحات ۹۵۲-۹۵۵
عنوان فارسی Electrocardiographic Manifestations of Benzodiazepine Toxicity
چکیده فارسی مقاله
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عنوان انگلیسی Electrocardiographic Manifestations of Benzodiazepine Toxicity
چکیده انگلیسی مقاله Background: The aim of this study was to evaluate and compare the clinical and ‎electrocardiographic (ECG) manifestations of benzodiazepines (BZs).‎ Methods: In this retrospective study, all BZ-poisoned patients hospitalized at Loghman ‎Hakim Hospital between September 2010 and March 2011 were evaluated. Patients’ ‎information including age, sex, time elapsed between the ingestion and presentation, ‎and type of the BZ used were extracted from the patients' charts and recorded. ECGs ‎on presentation to the emergency department (ED) were evaluated and parameters ‎such as PR interval, QRS duration, corrected QT, amplitude of S wave in lead I, height ‎of R wave and R/S ratio in the lead aVR were also measured and recorded.‎ Results: Oxazepam, chlordiazepoxide, lorazepam, alprazolam, diazepam, and ‎clonazepam were ingested by 9 (3%), 13 (4.4%), 29 (9.9%), 105 (35.8%), 65 (22.2%), ‎and 72 (24.6%) patients, respectively. Mean PR interval was reported to be 0.16 ± 0.03 ‎sec and PR interval of greater than 200 msec was detected in 12 (4.5%) patients. Mean ‎QRS duration was 0.07 ± 0.01sec and QRS≥120 msec was observed in 7 (2.6%) ‎cases. ‎ Conclusion: Diazepam is the only BZ that does not cause QRS widening and ‎oxazepam is the only one not causing PR prolongation. It can be concluded that if a ‎patient refers with a decreased level of consciousness and accompanying signs of BZ ‎toxicity, QRS widening in ECG rules out diazepam, whereas PR prolongation rules out ‎oxazepam toxicity.‎
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نویسندگان مقاله ناهید کاظم زاده | nahid kazemzadeh
department of forensic medicine and toxicology, iran university of medical sciences, tehran, iran.‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سعید محمدی | saeed mohammadi
department of forensic medicine and toxicology, iran university of medical sciences, tehran, iran.‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمدعلی امام هادی | mohammadali emamhadi
department of forensic medicine and toxicology, shahid beheshti university of medical sciences, tehran, iran.‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

عبداله امیرفرهنگی | abdollah amirfarhangi
‎ department of cardiology, hazrat rasoul akram p hospital, iran university of medical sciences, tehran, iran.‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حسین صناعی زاده | hossein sanaei zadeh
emergency department division of medical toxicology, hazrat ali-asghar p hospital, shiraz university of ‎medical sciences, shiraz, iran.‎

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-136&slc_lang=en&sid=en
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