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Iranian Journal of Toxicology، جلد ۴، شماره ۴، صفحات ۳۶۷-۳۷۲
عنوان فارسی Determining the complications, mortality, and treatment of patients hospitalized at Baharloo hospital due to oral hypoglycemic drugs toxicity in ۲۰۰۸-۹
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عنوان انگلیسی Determining the complications, mortality, and treatment of patients hospitalized at Baharloo hospital due to oral hypoglycemic drugs toxicity in 2008-9
چکیده انگلیسی مقاله Background: Glybenclamide and metformin are two of the most common oral hypoglycemic drugs which are often used in treatment of type II diabetes mellitus. Toxicity due to these drugs may occur intentionally, accidentally, or even at the normal dosage because of the progression of such internal diseases as renal dysfunction. Methods: In this case series study, 59 patients poisoned with oral hypoglycemic agents referring to Baharloo Hospital were evaluated between March 2009 and September 2010. Results: The most common clinical findings were lethargy (66.7%) and drowsiness (66.7%) that were mostly observed in patients who had concomitantly ingested glybenclamide and metformin. Metabolic acidosis was observed in 33.3% of the patients who had ingested metformin alone and 22.2 % of the patients who had ingested metformin together with glybenclamide. Some degrees of hypoglycemia were observed in 50.8% of the patients upon admission nevertheless, severe hypoglycemia was seen only in 17% of them. The majority of the patients got improved within 3 days of hospitalization and got discharged. Although due to the severity of toxicity and its associated complications, 22.8% of the patients needed more than 3 days of hospitalization, permanent neurological complications and mortality did not happen to any of the patients. Conclusion: Glybenclamide overdose leads to hypoglycemia and it can be prevented by careful monitoring of blood glucose and immediate treatment with intravenous dextrose, mostly occuring due to its hypoglycemic effects on the brain.
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نویسندگان مقاله بهنام بهنوش | behnam behnoosh
department of forensic medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فخرالدین تقدسی نژاد | fakhrodin taghdosi nejad
department of forensic medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد عارفی | mohammad arefi
department of forensic medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رسول روشنی | rasoul roshani
department of forensic medicine, tehran university of medical sciences, tehran iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد جمالیان | mohammad jamalian
department of forensic medicine, arak university of medical sciences, arak, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-21&slc_lang=en&sid=en
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