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Iranian Journal of Toxicology، جلد ۲، شماره ۳، صفحات ۲۱۱-۲۱۵
عنوان فارسی Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat
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عنوان انگلیسی Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat
چکیده انگلیسی مقاله Introduction: Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects. Material and Methods: Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood. Results: Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them. Conclusion: Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage.
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نویسندگان مقاله اکرم رنجبر | akram ranjbar
department of toxicology, hamedan university of medical sciences, h amedan, iran


رضوان صالحی دوست | rezvan salehidoost
shariati hospital tehran university of medical sciences, tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم بعیری | maryam baeeri
laboratory of toxicology, faculty of pharmacy, and pharmaceutical sciences research center


محمد عبدالهی | mohammad abdollahi
laboratory of toxicology, faculty of pharmacy, and pharmaceutical sciences research center
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-45&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده پژوهشی
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