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Iranian Journal of Toxicology، جلد ۲، شماره ۳، صفحات ۲۲۱-۲۲۷
عنوان فارسی Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice
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عنوان انگلیسی Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice
چکیده انگلیسی مقاله Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures in mice. Material and methods: The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group. Results: Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P< 0.001). Conclusion: Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice.
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نویسندگان مقاله کامبیز سلطان نژاد | kambiz soltaninejad
department of forensic toxicology, legal medicine organization of iran, tehran, iran


شاهین شادنیا | shahin shadnia
loghman-hakim hospital poison center and toxicology resaerch center,faculty of medicine, shahid beheshit medical sciences university, tehran, iran


فاطمه حسنی نژاد | fatemeh hasaninejad
department of toxicology, and pharmacology,faculty of pharmacy, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فریبا جابری | friba jabbari
department of toxicology, and pharmacology,faculty of pharmacy, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمد عبدالهی | mohammad abdollahi
department of toxicology, and pharmacology,faculty of pharmacy; and pharmaceutical sciences research center.tehran medical sciences university, tehran, iran
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-47&slc_lang=en&sid=en
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