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Iranian Journal of Toxicology، جلد ۱، شماره ۳، صفحات ۸-۸
عنوان فارسی Acute Liver Dysfunction Associated With Interferon-Beta-۱a (Avonex®) Use in A Young Female Patient with Relapsing-Remitting Multiple Sclerosis (RRMS)
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عنوان انگلیسی Acute Liver Dysfunction Associated With Interferon-Beta-1a (Avonex®) Use in A Young Female Patient with Relapsing-Remitting Multiple Sclerosis (RRMS)
چکیده انگلیسی مقاله Background: It has been reported that liver function alterations occur in 8–38% of patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon-beta in controlled clinical trials or in prospective but non-controlled studies. We report herein a case of symptomatic liver dysfunction associated with two-year-period of regular interferon-beta-1a (Avonex®) intramuscular injections in a young female patient with relapsing-remitting multiple sclerosis. Case: The patient was 19 year-old female with clinically proved RRMS, treated with interferon-beta-1a (Avonex®) 30 µg weekly by intramuscular injections for two years. She was referred with clinical symptoms of liver dysfunction including abdominal peri-umbilical and right upper quadrant pain, anorexia and malaise, that constipation, dark urine and icterus. Laboratory studies corroborated acute hepatitis state without any viral, autoimmune or drug-related causes. Patient's status improved after two weeks of conservative therapy and withholding interferon. Billirubin, liver function tests and liver enzyme values returned to normal. Conclusion: Interferon-beta compounds could have serious hepatic complications, and patients using interferon-beta-1a should regularly monitor their liver function.
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نویسندگان مقاله علیرضا رضایی آشتیانی | ali reza rezaei ashtiani
department of neurology, vali-e-asr. medical center,arak medical university, arak, iran


بابک زمانی | babak zamani
department of neurology,rasol-e-akram medical center, tehran, iran


محمد روحانی | mohammad rohani
department of neurology,rasol-e-akram medical center, tehran, iran
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-66&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده پژوهشی
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