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Iranian Journal of Toxicology، جلد ۱، شماره ۲، صفحات ۳-۳
عنوان فارسی Teratological Effects of Chlorpyrifos in Mice
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله Chlorpyrifos، Teratogenesis، Feto-Toxicology
عنوان انگلیسی Teratological Effects of Chlorpyrifos in Mice
چکیده انگلیسی مقاله Introduction: Chlorpyrifos (CPF), an organophosphate insecticide, was evaluated for potential teratogenic effects in mice. A single oral dose of insecticide (i.e. 72, 36 18 or 9 mg/kg) was given to the pregnant females on gestation day6 (GD6). These doses correspond 50, 25, 12.5 and 6.25% to the calculated LD50 value (144 mg/kg) for the pregnant mice. No signs of overt toxicity were observed at any of these doses. Method and Materials: Fetuses recovered from 18, 36 and 72 mg/kg groups showed a variety of morphological defects i.e. microcephaly, hydrocephaly, agnathia, anophthalmia, enlarged meningio-encepahlocoele, Spina-bifida, meromelia, micromelia, drooping wrists, rudimentary or kinky tails, round back, twisted spine, tortuous-limbs, flipper feet and sacral hygromas. Fetuses recovered from vehicle treated and 9mg/kg groups were apparently normal. Results: Statistical analysis of the data based on single factor ANOVA and Duncan’s Multiple Range Test have shown a dose dependent decrease in litter size (P < 0.001) along with averaged per litter: fetal weight (P < 0.01) and crown rump length (P < 0.05). The extent of ossification in embryonic skeleton decreased progressively with increased maternal CPF exposure. Conclusion: Based on these findings we conclude that, if treated on GD6, a single oral dose of 18 mg/kg CPF (12.5% of LD50) may lead to several craniofacial and skeletal anomalies in developing mice embryos, whereas its fetotoxic role is fairly dose dependent embryos.
کلیدواژه‌های انگلیسی مقاله Chlorpyrifos, Teratogenesis, Feto-Toxicology
نویسندگان مقاله خواجه رییس احمد | khawaja raees ahmad
department of biological sciences, assistant professor of zoology university of sargodha, sargodha. pakistan


عصمت الله | asmatullah
department of biological sciences, associate professor of zoology university of the punjab, lahore. pakistan
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-3&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده پژوهشی
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