این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۲۱، شماره ۲، صفحات ۱۲۶-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hereditary nonpolyposis colorectal cancer in northeastern Iran
چکیده انگلیسی مقاله Background: There are no data on familial aggregation of colorectal cancer (CRC) in northeastern Iran. The aim of this study was to determine the prevalence of early-onset CRC and patients suspected for hereditary non-polyposis colorectal cancer (HNPCC) based on the clinical criteria in this area. Materials and Methods: Documents were collected from two hospitals in Mashhad regarding 326 inpatients during 2013-2015. Demographics, clinical, and tumor-related features were recorded. Interviews were done to identify cancer in the family up to second-degree relatives. Results: 326 patients with CRC (48.5% male) were evaluated. The mean age at diagnosis was 55.44±14.85 years, with 91 patients (27.9%) below 45 years old. Eleven (3.4%) patients fulfilled the Amsterdam II criteria and 136 (41.7%) patients met at least one criterion of the revised Bethesda guideline. There was no difference between early- and late-onset CRC regarding the frequency of CRC in 1 st degree relatives or tumor site ( p =0.73, p =0.64). However, CRC in second-degree relatives and cases suspected for HNPCC were more common in early-onset of the disease ( p =0.022, p =0.024). The patients who fulfilled the Amsterdam II criteria had lower mean age and higher frequency of proximal cancer ( p =0.03, p =0.048). Conclusion: As CRC is common in the young population and CRC clustering and patients suspected for HNPCC are also frequently encountered, measures should be taken to CRC screening policy and genetic studies in this area.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله لادن گشایشی | ladan goshayeshi
gasteroenterology and hepatology department, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا خویی | aliraza khooie
pathology department, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عباس esmaieelzadeh | abbas esmaieelzadeh


مهلا رحمانی خرم | mahla rahmani khorram


کامبیز اخوان رضایت | kambiz akhavan rezayat


کامران غفارزادگان | kamran ghaffarzadegan


زهرا یوسفلی | zahra yousefli


امید ghanaiee | omid ghanaiee


علی بهاری | ali bahari


هومن مسنن مظفری | hooman mosannan mozaffari


آزیتا گنجی | azita ganji


علی مختاری فر | ali mokhtarifar


فرنود رجب زاده | farnood rajabzadeh


نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/1469
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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