این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۱۹، شماره ۲، صفحات ۸۶-۰
عنوان فارسی
چکیده فارسی مقاله Abstract Background : Cancer stem cells (CSC) of tumor cells have capability of self-renewal and differentiation characterized by multiple markers. Several studies have been conducted to identify these cells in colorectal cancer, including CD24. To evaluate the association of CD24expression with clinicopathologic features and survival, immunohistochemical(IHC) study in colorectal cancer tissue(paraffin blocks) and adjacent normal tissues was done. Methods : The expression of CD24 in 50 paraffin embedded samples of colorectal cancer and adjacent normal tissue in patients referred to Imam Khomeini Hospital, Sari was examined by IHC method. The relationship of clinical and pathological features in terms of metastasis, recurrence, type of treatment and kind of death due to cancer treatment with Cd24 expression was studied. Results : 50 cases studied (25 males and 25 females) with a mean age of 57.64± 9.13 years, range 93-28 years; 3 were mucinous carcinoma and 47 were adenocarcinoma. CD24 was positive in 29 and negative in 21 cases. According to this study,CD24 expression was correlated with the type of treatment ,surgery and chemotherapy together,(P-value: 0.04).It was shown that there was correlation between Cd24 expression and patient survival although it was not statistically significant. (Mean survival time based on the expression of CD24,in negative sampleswas 26.64 ± 18.15 and in positive samples 41.75 ±28.67months). There was no significant correlation betweenCD24 expression and other clinicopathologic factors (P-value> 0.05). Conclusion :  During the  study,  the relationship  between clinicopathologic  features of  colorectal cancer and  expression of stem cell  marker CD24 was observed.  To  confirm the results  more  studies with a  larger  sample size  is recommended .
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Correlation of Colorectal cancer stem cell marker CD24 expression with clinicopathologic features and survival of patients with colorectal cancer
چکیده انگلیسی مقاله Background : Cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. Several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker CD24. This study has evaluatedtheassociation of CD24 expression with clinicopathologic features and survival in an immunohistochemical(IHC) study that compared colorectal cancer tissues with adjacent normal tissues. Materials and Methods : The expression of CD24 in 50 paraffin embedded samples of colorectal cancer and adjacent normal tissue in patients referred to Imam Khomeini Hospital, Sari, Iran was examined by IHC. We studied the relationship between clinical and pathological features as well as the patient’s condition in terms of metastasis, recurrence, type of treatment and death due to cancer treatment. Results : The 50 cases studied included 25 males and 25 females with a mean age of 57.64± 9.13 years (range: 28-93 years) There were 3 mucinous carcinoma and 47 adenocarcinoma samples. CD24 was positive in 29 cases and negative in 21 cases. CD24 expression correlated with combined surgery and chemotherapytreatment ( p = 0.04). A correlation existed with patient survival but it was not statistically significant. The mean survival time of patients according to CD24 expression was 26.64±18.15 in cases that were CD24 negative and 41.75±28.67 months in cases that were CD24 positive. Correlation of CD24 expression with other clinicopathologic factors was not significant ( p >0.05). Conclusion : We have observed a relationship between the clinicopathologic feature of combined surgery and chemotherapy treatment to colorectal cancer stem cell marker expression. A nonsignificant correlation also existed with patient survival. To confirm these results, we recommend additional studies with larger sample sizes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله آناهیتا نصرتی | anahita nosrati
md, department of pathology,sari, mazandaran university of medical science

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

فرشاد نقش وار | farshad naghshvar
md, department of pathology,sari, mazandaran university of medical science

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

ژیلا ترابی زاده | zhila torabizadeh


فاطمه صالحی | fateme salehi
md, department of pathology,sari, mazandaran university of medical science

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/1306
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات