این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۱۸، شماره ۳، صفحات ۱۸۱-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of Silymarin on Reducing Liver Aminotransferases in Patients with Nonalcoholic Fatty Liver Diseases
چکیده انگلیسی مقاله Background The hepatoprotective effects of silymarin have been confirmed by various researchers worldwide; however few studies are available about the therapeutic impact of silymarin on the level of aminotransferases in patients with nonalcoholic steatohepatitis (NASH). Our purpose is to determine whether silymarin improves the serum level of aminotransferases in patients with NASH. Materials and Methods This was a double blind, randomized, placebo-controlled trial performed on 100 patients with NASH. Subjects were randomized to receive silymarin (140 mg/q12h) for three months or placebo, given in the same manner. A blood sample was drawn at baseline (before treatment) and after completion of the treatment schedule to assess serum aminotransferase levels. We measured body mass index (BMI) before and after administration of the treatments for both groups of patients. Results  There were insignificant changes in BMI for both groups. The mean serum alanine aminotransferase (ALT) level in the case group significantly changed from 84.06 to 68.54 IU/mL following treatment with silymarin ( p ‹0.001), however this change was not significant in the control group. The mean serum aspartate aminotransferase (AST) level in the case group significantly decreased from 71.94 to 54.70 IU/mL after treatment with silymarin. This change in the placebo group was not significant (from 62.94 to 61.56 IU/mL). Conclusion  Administration of silymarin can effectively reduce liver aminotransferases without any changes in BMI in patients with NASH disease.  Normal 0 false false false EN-US X-NONE FA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;}
کلیدواژه‌های انگلیسی مقاله Silymarin,NASH,ALT,AST
نویسندگان مقاله محسن مسعودی | mohesn masoodi


امیر منصور رضادوست | amirmansoor rezadoost


محمد پناهیان | mohammad panahian


مهدی وجدانیان | mahdi vojdanian


نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/1263
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات