این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۱۵، شماره ۴، صفحات ۲۸۳-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evolutionary Dynamics of Helicobacter pylori cagA and vacA Genes in Iran and their Association with Clinical Outcomes
چکیده انگلیسی مقاله Background: There is a relationship between specific genotypes of Helicobacter pylori cagA and vacA genes and the increased risk of peptic ulcer diseases and gastric cancer. These genes also possess strong patterns of geographical differentiation. The present study aims to determine the patterns of variation of the virulence genes in Iran and their association with clinical status. Materials and Methods:Sequence fragments for cagA and vacA were obtained from a total of 147 H. pylori isolates from diverse geographical and ethnic sources within Iran. We used phylogenetic methods to determine the patterns of allelic diversity, and the relationship between evolutionary lineages and clinical status. Results:Phylogenetic analyses of Iranian cagA gene disclosed four lineages, whereas the vacA gene had two distinct lineages. The cagA lineage II showed extensive genetic diversity compared with lineage I. cagA lineages III and IV disclosed mixed ancestries with recombinant nucleotides that originated from lineages I and II. Iranian strains with vacA lineage II genotype were significantly cagA+ (> 90%, p = 0.0) and correlated with a higher rate of peptic ulcers in infected individuals (p =0.003). Most strains in the cagA lineage I showed a vacA lineage II genotype (p = 0.003) and significantly correlated with an increased risk of peptic ulcers in infected individuals (p = 0.022). Strains with cagA lineage III genotype significantly correlated with gastritis (p = 0.0). Conclusion:The increased level of allelic diversity in the virulence genes shows strong evolutionary dynamics, resulting in the emergence of new clonal genealogies of the cagA gene within Iran. Particular lineages of the Iranian cagA and vacA genes correlate with peptic ulcer diseases.
کلیدواژه‌های انگلیسی مقاله H. pylori,Genetic diversity,Clinical status,vacA,cagA,Iran
نویسندگان مقاله سعید لطیفی نوید | saeid latifinavid


فریده سیاوشی | farideh siavoshi


حافظ فاخری | hafez fakheri


افسانه شریفیان | afsaneh sharifian


نوبخت | hossein nobakht


رامین طواف زاده | ramin tavafzadeh


حسن سلمان روغنی | hasan salmanroghani


مهران بهبهانیان | mehran behbahanian


صادق massarrat | sadegh massarrat


رضا ملک زاده | reza malekzadeh


نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/518
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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