این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۱۳، شماره ۳، صفحات ۱۹۲-۰
عنوان فارسی
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عنوان انگلیسی Prevalence of Celiac Disease in Patients with Irritable Bowel Syndrome
چکیده انگلیسی مقاله Background: Celiac disease (CD) may be misdiagnosed as Irritable Bowel Syndrome (IBS) resulting in long delays in diagnosing CD. There are contradictory reports on the association of CD with IBS.Appropriateness of screening all patients with IBS for CD and how to screen them are still under question. Materials and Methods: In a cross-sectional study, 328 IBS patients (Rome II) referred to the Poursina Hakim Gastroenterology Clinic were investigated for CD. Total serum anti-tissue transglutaminase IgA (anti-tTG IgA) concentration was measured in all patients. In IgA deficient cases, antigliadin antibody (AGA) IgG concentration was also measured. Moreover, in patients who underwent upper endoscopy (as their necessary workup) duodenal biopsies were taken. Results: Fifty-eight patients were excluded. The remaining patients were 166 (61.5%) women and 104 (38.5%) men with the mean age of 35.3 years (SD = 11.8). No one had positive serological test of IgAantitTG antibody. Five patients were IgA deficient; none of them had positive IgG AGA. Duodenal biopsies were taken in 60 patients and pathologic evaluation showed 53Marsh 0, threeMarsh I, threeMarsh II, and one Marsh IIIa. Only the patient with Marsh IIIa adhered to gluten-free diet (GFD) which led to decrease in severity of symptoms. In patients who did not adhere to GFD, no one had positive serological test after 12 months of follow-up. Conclusion: Prevalence of CD in patients with IBS referred to outpatient gastroenterology clinic might be significant but serum anti-tTG IgAantibody is not helpful in detecting CD in these patients. Further studies are needed to clarify this issue.
کلیدواژه‌های انگلیسی مقاله Celiac disease,Irritable bowel syndrome,Screening.
نویسندگان مقاله محمدحسن امامی | mohammadhasan emami


سهیلا کوهستانی | soheila kouhestani


علی غلامرضایی | ali gholamrezaei


مرضیه هاشمی | marzieh hashemi


پروین محزونی | parvin mahzouni


مصطفی رییسی | mostafa raeisi


حامد دقاق زاده | hamed daghaghzadeh


هوشنگ دانشگر | houshang daneshgar


نشانی اینترنتی http://www.govaresh.org/index.php/dd/article/view/641
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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