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Iranian Journal of Medical Physics، جلد ۱۲، شماره ۴، صفحات ۲۷۸-۲۸۳
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عنوان انگلیسی Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis
چکیده انگلیسی مقاله Introduction One of the important applications of nuclear physics in medicine is the use of radioactive elements as radiopharmaceuticals. Metastatic bone disease is the most common form of malignant bone tumors. Samarium-153-ethylene diamine tetramethylene phosphonate (153Sm-EDTMP) as a radiopharmaceutical is used for pain palliation. This radiopharmaceutical usually emits beta particles, which have a high uptake in bone tissues. The purpose of this study was to calculate the radiation dose distribution of 153Sm-EDTMP in bone and other tissues, using MCNPX Monte Carlo code in the particle transport model. Materials and Methods Dose delivery to the bone was simulated by seeking radiopharmaceuticals on the bone surface. The phantom model had a simple cylindrical geometry and included bone, bone marrow, and soft tissue. Results The simulation results showed that a significant amount of radiation dose was delivered to the bone by the use of this radiopharmaceutical. Conclusion Thebone acted as a fine protective shield against rays for the bone marrow. Therefore, the trivial absorbed dose by the bone marrow caused less damage to bone-making cells. Also, the high absorbed dose of the bone could destroy cancer cells and relieve the pain in the bone.
کلیدواژه‌های انگلیسی مقاله Dose Distribution, MCNPX Code, 153Sm-EDTMP
نویسندگان مقاله فاطمه رازقندی | fatemeh razghandi
department of physics, school of sciences, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

رضا ایزدی | reza izadi
department of physics, school of sciences, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

علی مولوی | ali mowlavi
department of physics, hakim sabzevari university, sabzevar, iran international centre for theoretical physics, associate and federation schemes, medical physics field, trieste, italy

سازمان اصلی تایید شده: دانشگاه حکیم سبزواری (Hakim sabzevari university)

نشانی اینترنتی http://ijmp.mums.ac.ir/article_6843.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Paper
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