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Iranian Journal of Medical Physics، جلد ۸، شماره ۳، صفحات ۲۱-۲۹
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عنوان انگلیسی Pathological Assessment of Brain White Matter in Relapsing-Remitting MS Patients using Quantitative Magnetization Transfer Imaging
چکیده انگلیسی مقاله Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a relatively new method to investigate pathologic processes of the brain tissue occurring in MS patients. Material and Methods: Voxel-based analyses allow regional comparisons between groups to be made for the whole brain in a single analysis. This is done by coregistering data from all individual subjects to a reference brain, generally referred to as the "standard space", and then comparing them on a voxel-by-voxel basis. This study aimed to analyze whole-brain quantitative T1 maps, not to find global changes or changes in selected regions, but specifically to investigate the spatial distribution throughout the brain of T1 increases in MS WM with respect to control WM. In this study, 11 healthy controls, 10 relapsing-remitting (RR) MS patients and 13 CIS patients were studied using MT-MRI imaging. MT parameters, including magnetization transfer ratio (MTR), magnetization transfer rate between free protons and restricted macromolecular protons, Ksat and longitudinal relaxation times (with and without MT saturation pulse), T1sat and T1free values were evaluated. Results: The results showed that, at a group level, there is widespread involvement of WM throughout the brain in CIS MS and especially in RRMS, where a significant T1 increase was found in 15.58% of WM voxels (normals < RR). Discussion and Conclusion: This study demonstrates that WM in large parts of the brain is susceptible to disease processes in RR and CIS MS
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نویسندگان مقاله خدارحم پهلوان | khodarahm pahlevan
m.sc. of medical physics, medical physics dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نادر ریاحی عالم | nader riyahi alam
prof., medical physics dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد حسین حریرچیان | mohammad hossein harirchian
associate professor, neurology dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کاووس فیروزنیا | kavoos firouznia
associate professor, radiology dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مجید شکیبا | majid shakiba
research assistant, medical image center, imam khomeini hospital, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا بزرگی | alireza bozorgy
neurology resident, neurology dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مرتضی بختیاری | morteza bakhtiary
m.sc. of medical physics, medical physics dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهروز رفیعی | behrooz rafiei
m.sc. of medical physics, imaging center, imam khomeini hospital, tehran, iran


معصومه فولادی | masumeh fouladi
m.sc. of medical physics, medical physics dept., faculty of medicine, tehran university of medical sciences, teheran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijmp.mums.ac.ir/article_7226.html
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