این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۸، شماره ۱، صفحات ۱۹-۲۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hyperthermia Effects in the Presence of Gold Nanoparticles Together with Chemotherapy on Saos-2 Cell Line
چکیده انگلیسی مقاله Introduction: Hyperthermia created by microwave (MW), infrared, ultrasound and other methods, is often utilized as an adjuvant to sensitize cancer cells to the effects of chemotherapy and radiation therapy. We investigated the efficacy of hyperthermia using MW in synergy with chemotherapy in the presence and absence and gold nanoparticles (GNPs). Material and Methods: After culturing and proliferation of the Saos-2 cell line derived from human osteogenic sarcoma, the cells were incubated at two concentrations of GNPs in two diameters of 20 and 40 nm and in the absence and presence of doxorubicin in different groups. Forty eight hours after irradiating the cells with MW up to a temperature of 42°C, cell survival rate was determined using the MTT method, in order to study the effectiveness of the therapeutic parameters. Results: Cell survival in the presence of GNPs was greater than 95%. After chemotherapy by doxorubicin with and without 40 nm GNPs, cell survival rates were determined as 62.8% and 37.1%, declining down to 17% and 4.1% respectively following the combined treatment with MW and chemotherapy in the presence of 20 and 40 nm GNPs. Discussion and Conclusions: GNPs did not induce any cytotoxicity by themselves; their presence along with MW provided a reduction in survival rate that was comparable in severity with the lethal effects of doxorubicin. MW hyperthermia with GNPs produced a higher treatment efficiency in comparison to similar groups in which GNPs were absent. The synergism observed between hyperthermia and chemotherapy was dependent in GNPs' size and concentration. This finding could be caused by increased uptake of doxorubicin by the cells in the presence of GNPs.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله آمنه سازگارنیا | ameneh sazgarnia
assistant professor of medical physics, medical physics research center, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد حسین بحرینی طوسی | mohammad hosein bahreyni toossi
professor of medical physics, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه حاجی قهرمانی | fatemeh haji ghahremani
m.sc. in medical physics, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امید رجبی | omid rajabi4
associate professor of medicinal chemistry, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سید امیر آل داوود | seyed amir aledavood
assistant professor of oncology, omid hospital, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حبیب ا اسماعیلی | habib ollah esmaily
associate professor of biostatistics, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijmp.mums.ac.ir/article_7204.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Paper
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات