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Iranian Journal of Medical Sciences، جلد ۴۱، شماره ۴، صفحات ۲۶۵-۰
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عنوان انگلیسی Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: The cardioprotective effect of ischemic preconditioning has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ischemic preconditioning (RIPC). We hypothesized that the extension of RIPC has more cardioprotective effect in patients undergoing coronary artery bypass graft (CABG) surgeries. Methods: In this triple-blind randomized clinical trial study, 96 patients were randomly divided into 3 groups and two blood pressure cuffs were placed on both upper and lower extremities. In group A, only upper extremity cuff and in group B upper limb and lower limb cuff was inflated intermittently and group C was the control group. RIPC was induced with three 5-min cycles of cuff inflation about 100 mmHg over the initial systolic blood pressure before starting cardiopulmonary bypass. The primary endpoints were troponin I and creatine phosphokinasemyoglobin isoenzyme (CK-MB). Results: Six hours after the termination of CPB, there was a peak release of the troponin I level in all groups (group A=4.90 ng/ml, group B=4.40 ng/ml, and group C=4.50 ng/ml). There was a rise in plasma CK-MB in all groups postoperatively and there were not any significant differences in troponin I and CK-MB release between the three groups. Conclusion: RIPC induced by upper and lower limb ischemia does not reduce postoperative myocardial enzyme elevation in adult patients undergoing CABG. Trial Registration Number: IRCT2012071710311N1
کلیدواژه‌های انگلیسی مقاله Ischemic preconditioning, Coronary artery bypass, Troponin I
نویسندگان مقاله علی کرمی | ali karami
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد باقر خسروی | mohamad bagher khosravi
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مسیح شفا | masih shafa
department of cardiac surgery, faghihi hospital, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سیمین عظمتی | simin azemati
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سعید خادمی | saeed khademi
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سید hedayatalla اخلاق | seyed hedayatalla akhlagh
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

بهزاد مقصودی | behzad maghsodi
shiraz anesthesiology and critical care research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/1189
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