این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Sciences، جلد ۳۷، شماره ۱، صفحات ۳۹-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids
چکیده انگلیسی مقاله Background: Long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. Glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). Piper sarmentosum is a local herb that possesses the ability to inhibit 11-βHSD1 enzyme activity. We aimed to determine the effects of Piper sarmentosum water extract on 11-βHSD1 expressions and activity in the bones of glucocorti-coid-treated adrenalectomized rats. Methods: Forty male Sprague–Dawley rats (200-250 g) were used. Twenty-four animals were adrenalectomized and received intramuscular injection of dexamethasone (120 μg/kg/day). They were simultaneously administered with either Piper sarmentosum water extract (125 mg/kg/day), GCA (120 mg/kg/day) or distilled water as vehicle by oral gavage for two months. Eight animals were sham-operated and given vehicle daily, i.e. intramuscular olive oil and oral distilled water. Results: Following two months treatment, dexamethasone-treated adrenalectomized rats had significantly lower 11β-HSD1 dehydrogenase activity and higher 11β-HSD1 expression in the femoral bones compared to the sham-operated and baseline group. The rats supplemented with Piper sarmentosum water extract had significantly higher 11β-HSD1 dehydrogenase activity and lower 11β-HSD1 expression in the bones. Conclusion: The results showed that Piper sarmentosum water extract had the ability to prevent glucocorcoticoid excess in the bones of glucocorticoid-treated adrenalectomized rats through the local modulation of 11β-HSD1 expression and activity, and may be used as prophylaxis for osteoporosis in patients on long-term glucocorticoid treatment.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله farihah hj suhaimi | farihah hj suhaimi
department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


elvy suhana محمد ramli | elvy suhana mohd ramli
department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


ایما nirwana soelaiman | ima nirwana soelaiman
department of pharmacology, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


faizah احمد عثمان | faizah othman
department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


fairus احمد | fairus ahmad
department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


احمد nazrun shuib | ahmad nazrun shuib
department of pharmacology, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


norazlina محمد | norazlina mohamed
department of pharmacology, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia


norliza محمد | norliza muhammad
department of pharmacology, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia
نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/311
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات