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Iranian Journal of Medical Sciences، جلد ۳۷، شماره ۱، صفحات ۴۷-۰
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی HESA-A Exerts Its Cytoprotective Effects through Scavenging of Free Radicals: An in Vitro Study
چکیده انگلیسی مقاله Background: Natural medicines have been recently considered more reasonable for human use most notably due to their safety and tolerance. HESA-A is a marine-originated herbal medicine with a variety of healing effects. However, its exact biological mechanism is not clear. The pre-sent study aimed at the evaluation of the HESA-A antioxidant effect. Methods: Chinese hamster ovary (CHO) and human embryonic kidney (HEK293T) cells were treated with different concentrations of HESA-A and H2O2 followed by cell proliferation assays. The antioxidant effect of the HESA-A preparations was evaluated by an antioxidant assay kit. Results: The viability of CHO and HEK293T cells were about 89% following their incubation with 100 and 200 ng/ml HESA-A, respectively for 1.5 hrs. However, when the cells were incubated with concentrations of 300 ng/ml or more, the cell viability significantly decreased to 48% compare to the control cells. The cytotoxic effects of H2O2 were observed after 2 hrs of incubation of the HEK293T or CHO cells with 10 mM or 16 mM H2O2, respectively, while in the presence of HESA-A the cytotoxicity was significantly decreased. Antioxidant assay revealed that HESA-A scavenges free radicals. Conclusion: The findings indicate that HESA-A had cytoprotective effects in vitro, and that such an effect might be due to antioxidant properties.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمد علی شکرگزار | mohammad ali shokrgozar
national cell bank of iran, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

مهریار حبیبی رودکنار | mehryar habibi roudkenar
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

پریسا بهمنی | parisa bahmani
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

راحله حلبیان | raheleh halabian
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

آمنه محمدی روشنده | amaneh mohammadi roushandeh
department of anatomy, faculty of medicine, medical university of hamadan, hamadan, iran


علی جهانیان نجف آبادی | ali jahanian najafabadi
department of molecular biology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/312
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زبان مقاله منتشر شده en
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