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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۲، صفحات ۶۷-۰
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عنوان انگلیسی Polymorphisms in the Apolipoprotein E Region and Severity of Multiple Sclerosis
چکیده انگلیسی مقاله Background: The apolipoprotein E (APOE) polymorphism is known to affect various neurologic disorders with different effects on the immune system and CNS repair. However, previous studies on possible modulation of the clinical course of multiple sclerosis (MS) by APOE polymorphism have been inconsistent. Objective: To clarify the issue for MS patients' management and future research. Methods: The present cross-sectional study investigated 81 patients with clinically proven MS and related their clinical and demographic findings to the allelic polymorphism of the APOE gene. The genotype distribution of patients with MS was compared with a comparison group of 93 asymptomatic elderly volunteers. Results: Significant differences were found in the distribution of e 4 allele between patients with MS and the comparison group (9.3% vs. 0.5%; p< 0.001). An analysis of disease progression in 81 patients with MS indicated that APOE e 4 carriers are more likely to be affected with severe disease. Conclusion: The results obtained suggested that APOE genotype affected susceptibility to MS and indicated an association of the APOE e 4 allele with a more severe course of the disease. 
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نویسندگان مقاله v هادوی | v hadavi
dept. of human genetics amp;amp; anthropology, school of public health amp;amp; institute of public health research, tehran university of medi-cal sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

d d فرهود | d d farhud
national research center for genetic engineering and biotechnology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m h صنعتی | m h sanati
national research center for genetic engineering and biotechnology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s m نبوی | s m nabavi
shahed medical university, depart-ment of neurology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m سیدیان | m seyedian
roozbeh hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m هوشمند | m hushmand
national research center for genetic engineering and biotechnology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m یونسیان | m younesian
dept. of environmental health engineering , school of public health amp;amp; institute of public health research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2332
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زبان مقاله منتشر شده en
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