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Iranian Journal of Medical Sciences، جلد ۲۸، شماره ۲، صفحات ۸۱-۰
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عنوان انگلیسی Laboratory Monitoring of Cyclosporine Pre-dose Concentration (C0) After Kidney Transplantation in Isfahan
چکیده انگلیسی مقاله Background: Cyclosporine is the main immunosuppressive agent used in organ transplantation which leads to considerable improvement in graft survival. The large inter- and intra- patient variability in cyclosporine pharmacokinetics coupled with the agent’s narrow therapeutic index and adverse effects necessitate therapeutic monitoring of cyclosporine blood levels. Objective: The aim of this study was to determine the extent of variability following oral administration of cyclosporine after kidney transplantation, and provide guidelines for administration of cyclosporine in Isfahan/Iran Methods: The results of 2163 cyclosporine pre-dose blood samples obtained from 647 kidney transplant recipients (208 females, 439 males) with a median age of 34 years (range 11-54 years) were studied. Concentration of cyclosporine in the whole blood was determined by a radioimmunoassay using monoclonal antibodies specific for the drug. Statistical analyses were performed using SPSS. Results: The frequency distribution of C 0 and daily oral dosage of cyclosporine exhibited wide interindividual variability. Cyclosporine oral dosage regimen ranged from 100 mg to 400 mg. Trough cyclosporine blood concentration (C 0 ) ranged from 18 ug/l to 1400 ug/l. The results of cyclosporine whole blood levels in 56% were always below the suggested therapeutic range (less than 200 ug/l) and in 14% of the samples seemed to be associated with the occurrence of toxic side effects. There were no significant differences in the median trough levels of kidney recipients according to gender ( p = 0.36 ). Conclusion: For long-term management of kidney transplant recipients and in order to further optimize the use of cyclosporine, it is essential to standardize laboratory monitoring and clinical investigation of this agent.
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نویسندگان مقاله z طلوع قمری | z tolou ghamari
school of pharmacy, isfahan university of medical sciences and health services, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

a a پالیزبان | a a palizban
school of pharmacy, isfahan university of medical sciences and health services, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2439
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