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Iranian Journal of Medical Sciences، جلد ۲۷، شماره ۱، صفحات ۲۲-۰
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عنوان انگلیسی Role of Nitric Oxide and ATP-Sensitive K+ Channels in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in Rabbit
چکیده انگلیسی مقاله Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (K ATP ) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 New Zealand white rabbits, in two groups, under general anesthesia with sodium pentobarbital. N-omega-nitro-L-arginine methyl ester (L-NAME) and glibenclamide were administered locally and systemically before and during induction of hypercapnia. Results: The change in cerebral blood flow was not significant following local and systemic L-NAME administration, showing a non-significant role of local and systemic NO in regulation of rabbit basal cerebral blood flow. Hypercapnia increased cerebral blood flow by 17.3±4.4% before and 17.3±5.8% after local, and 5.8±3.2% (p< 0.05) after systemic L-NAME administration. The change in cerebral blood flow was not significant after local and systemic administration of glibenclamide indicating a lack of K ATP channel role in basal blood flow regulation. Hypercapnia increased cerebral blood flow by 27.2±8.7% before and 24.7±6.4% after local, and 49.3±9.7% after systemic administration of glibenclamide (p: NS in both cases). Conclusion: Regional NO production had no role in basal cortical blood flow regulation and systemic NO contributed to 66% increment in cerebral blood flow during hypercapnia. Also, the K ATP channels did not mediate the effect of NO or other vasodilators responsible for increasing cerebral blood flow during hypercapnia.
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نویسندگان مقاله h نجفی پور | h najafipour


آزاده وکیلی | a vakili


m یگانه حاج احمدی | m yeganeh hadj ahmadi


f اسماعیلی | f esmaieli


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2617
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