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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۵، صفحات ۳۸۵-۳۹۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Improvement of dermal delivery of tetracycline using vesicular nanostructures
چکیده انگلیسی مقاله The objective of this investigation was to study the potential use of nanoliposomes and nanotransfersomes in dermal delivery of tetracycline hydrochloride (TC) for acne treatment. Vesicular nanostructures were prepared by thin film hydration method and evaluated for their size, zeta potential, morphology, and entrapment efficiency. Minimal inhibitory concentration values of TC-loaded vesicles were evaluated and compared with TC aqueous solution against Staphylococcus epidermis . In vitro drug release and ex vivo drug permeation through the excised rat skin were performed to assess drug delivery efficiency. Particle size, zeta potential, and entrapment efficiency of prepared nanoliposomes and nanotransfersomes were found to be 75 and 78 nm, 17 and 7 mV, and 45 and 55%, respectively. Antimicrobial analysis indicated that there was no difference between vesicular formulations and aqueous solution of TC. In vitro drug release study indicated that nanoliposomes could release TC 2.6 folds more than nanotransfersomes, and skin permeation study showed that the permeability of TC-loaded nanotransfersomes was 1.6 times higher than nanoliposomes which was also confirmed by fluorescence microscope imaging. These findings concluded that nanoliposomal and especially nanotransfersomal formulations could be proposed as the potential approach for better therapeutic performance of TC against acne.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Azam Hasanpouri
2Hematology Oncology Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Farzaneh Lotfipour
3Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, I.R. Iran. 4Zanjan Pharmaceutical Nanotechnology Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.


| Saeed Ghanbarzadeh
5Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Hamed Hamishehkar


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1848
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-756700.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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