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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۵، صفحات ۴۴۰-۴۴۹
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چکیده فارسی مقاله
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عنوان انگلیسی Atorvastatin mitigates cyclophosphamide-induced hepatotoxicity via suppression of oxidative stress and apoptosis in rat model
چکیده انگلیسی مقاله Cyclophosphamide (CP), as a chemotherapy drug, induces hepatotoxicity through causing oxidative stress. Atorvastatin (ATV) at a low dose has antioxidant and anti-inflammatory properties. The present study was designed to investigate the protective effects of ATV against CP-induced hepatotoxicity in rat. In this experimental study, 32 rats were treated with ATV orally at a dose of 10 mg/kg for 10 consecutive days, 5 days before and 5 days after the administration of a single intraperitoneal injection of CP (150 mg/kg). The hepatoprotective effect of ATV was evaluated by measuring liver function markers, oxidative markers, histological and immunohistochemical assays. The biochemical results showed that administration of CP increased hepatic biomarkers enzymes as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels. CP increased malondialdehyde (MDA), protein carbonyl (PC) and decreased glutathione (GSH) content in rats. Moreover, administration of CP was associated with periportal leucocyte infiltration, dilation sinusoids, hepatocyte vacuolation, congestion and hemorrhage in livers of rats. CP significantly increased immunoreactivity of caspase-3 as a marker of apoptosis in liver tissue. ATV markedly mitigated liver injury through reduction in oxidative stress biomarkers, histopathological findings and apoptosis. The antioxidant and anti-apoptotic activities of ATV are main proposed mechanisms involved in its hepatoprotective effects against CP-induced hepatic injury.
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نویسندگان مقاله | Maedeh Hamzeh
3Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Seyed Jalal Hosseinimehr
1Department of Anatomy and Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Ali Reza Khalatbary
4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran. 5Pharmacutical Science Research Center, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Hamid Reza Mohammadi
2Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran. 4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Ayat Dashti
1Department of Anatomy and Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Fereshteh Talebpour Amiri


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1854
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-756706.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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