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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۵، صفحات ۴۶۹-۴۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Isolation of dioscin-related steroidal saponin from the bulbs of Allium paradoxum L. with leishmanicidal activity
چکیده انگلیسی مقاله Allium s are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. Allium paradoxum L. is a common edible vegetable in north regions of Iran, especially in Mazandaran province, where it is named “Alezi” and considerably used as a raw vegetable, to make dishes, and as a medicinal plant. Phytochemical investigation of chloroform-methanol extract of the plant resulted in the isolation and identification of a dioscin related steroidal saponin, using comprehensive spectroscopic methods including 1D and 2D NMR, its chemical structure was determined as (25R)-spirost-5-en-3b-ol,3-O-α-rhamnopyranosyl-(1 → 4)-α-rhamnopyranosyl-(1 → 4)-[a-rhamnopyranosyl-(1 → 2)]-glucopyranoside. Investigation of in vitro antileishmanial activity of the isolated compound, in 10 and 50 µg/mL concentrations, exhibited significant leishmanicidal effects ( P < 0.001) against the promastigotes of Leishmania major. The results established a valuable basis for further studies about A. paradoxum and anti-parasitic activity of steroidal saponins.
کلیدواژه‌های انگلیسی مقاله Allium paradoxum,Leishmania,Saponins,Structure elucidation.
نویسندگان مقاله | Fatemeh Rezaee
Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Behzad Zolfaghari
Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Masoud Sadeghi Dinani


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1858
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-756709.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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