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Basic and Clinical Cancer Research، جلد ۶، شماره ۴، صفحات ۳۷-۴۷
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عنوان انگلیسی Comparison of Anti-tumor Properties of the Cell walls of Saccharomyces Cerevisiae and Saccharomyces Boulardi Probiotics, individually and in Combination with Iron Nanoparticles on K562 Cancer cell line
چکیده انگلیسی مقاله Background: Chronic myeloid leukemia is a common cancer in human and chemical therapy is a routine method for treatment that has some side effects. So the goal of this study was the use of natural compound such as cell wall obtained from Saccharomyces cerevisiae ( S. cerevisiae ) and Saccharomyces boulardi ( S. boulardi ) and iron nanoparticles on the growth inhibition of K562 cell line. Methods: For cell wall preparation both yeast were cultured in a basic medium at aerobic condition and 28 °C. Then the medium was centrifuged and precipitant washed with sterile buffer and the cells disrupted by sunicator. Also iron nanoparticles were prepared by biological method. Anti cancer property of different concentrations of the yeasts cell wall with iron nanoparticles were assayed by MTT and electrophoresis methods. Results : The results showed that S. boulardi cell wall significantly (p=0.029) inhibits the growth of K562 cell line compared to S. cerevisiae . Also iron nanoparticles significantly (p=0.021) inhibit K562 cell line. Results revealed that combination the iron nanoparticles with both yeasts cell wall decreased anti cancer property but this was not significant at the level of p< 0.05. Conclusion : Based on this finding it should be concluded that combination of iron nanoparticles with Saccharomyces cell walls could inhibit the growth of K562 cell line in vitro. But these anti cancer properties would warrant further study on the clinical application of yeast cell wall.
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نویسندگان مقاله سالار mokriani | salar mokriani
department of biology, faculty of basic science, urmia islamic azad university

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

امیر tokmachi | amir tokmachi
department of biology, faculty of basic science, urmia islamic azad university

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مجید نوجوان | majid nojavan
department of pathobiology and quality control, urmia lake research institute, urmia university

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/115
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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